the project / study 2
Ecology of Campylobacter infection on farms: infection of people through environment and food
This study addresses the following hypotheses:
- Animal production acts as a multiplier of Campylobacter and a source of environmental contamination and subsequent livestock infection
- Microbial communities that occur in these environments impact on ecology of Campylobacter
- Livestock strains are more common in the environment than those associated with broiler production
To achieve the aims of the study, intensive longitudinal sampling is being conducted on a dairy and a broiler chicken farm over two years. The population biology of the Campylobacter strains recovered from the environment and the food animals will be characterised using whole genome sequencing so that changes in population structures can be determined. Survival of selected Campylobacter strains in the environment will be measured using relevant models and the impact of environmental exposure on subsequent virulence will be examined using in vitro models and chicken infection.